Publications

2025

• Resolved DEM-CFD coupling for wave-armour blocks interactions
  
  • Barcet Matthieu
  • Benguigui William
  • Laviéville Jérôme
  • Benoit Michel
  • Wachs Anthony
  • Fede Pascal
  • Bonometti Thomas
  Ocean Engineering, Elsevier, 2025, 337, pp.121865. The present work aims to tackle breakwater stability challenges through an innovative numerical deterministic method using a resolved DEM-CFD (Discrete Element Method—Computational Fluid Dynamics) strategy, which simulates the individual motions of armour units within a fluid solver. To achieve this, a coupling between a DEM code and a CFD code is implemented and validated. The fluids (air and water) are solved using a Eulerian–Eulerian CFD solver, and the contacts between blocks are solved using a DEM code. The solids are defined within the fluid solver using a discrete forcing approach and are therefore fully resolved. In this way, the fluid solver enables the prediction of object motions with complex shapes such as tetrapods. To couple the codes, forces exerted on the solids are calculated in the fluid solver and sent to the DEM solver. Then, contact and gravity forces are computed and added to the fluid forces. The DEM solver then computes the new positions and velocities of the bodies, which are retrieved by the fluid solver. An experimental study is performed on a fixed and instrumented idealized breakwater to evaluate the wave forces acting on a coastal structure. The experiments are then numerically reproduced to validate the numerical model. Simulations of the impact of solitary waves on a row of mobile isolated tetrapods laid on a horizontal berm are then performed using the DEM-CFD coupling. The importance of initial placement and friction parameters is investigated to show the sensitivity to these parameters. (10.1016/j.oceaneng.2025.121865)
  DOI : 10.1016/j.oceaneng.2025.121865
• Dam-break flow over various obstacles configurations
  
  • Beteille Elisa
  • Larrarte Frederique
  • Boyaval Sebastien
  • Demay Eric
  • Le Minh-Hoang
  Journal of Ecohydraulics, Taylor & Francis, 2025, 63, pp.156-170. Fast floods resulting from the failure of hydraulic structures can be characterized by ‘dam-break’ type waves. They pose catastrophic risks to downstream populations and result in severe structural damage, especially in urban areas. To assess and mitigate these risks, it is essential to forecast the influence of urban forms on flooding severity at a global scale. This paper provides datasets from reduced-scale physical experiments of transient flow through various obstacles configurations. The experiments are conducted in a rectangular horizontal open channel, where flow conditions are achieved by rapidly opening a gate holding a volume of water. To assess the impact of obstacle configurations on flow behaviour, two obstacle sizes are investigated, along with one idealized city layout. The experiments provide complete water hydrographs upstream and downstream of the gate. Additionally, the good performance of the code_saturne computational fluid dynamics (CFD) solver and the volume-of-fluid (VOF) method in numerically simulating the experiments is demonstrated. (10.1080/00221686.2025.2460020)
  DOI : 10.1080/00221686.2025.2460020
• LRP1 involvement in FHIT-regulated HER2 signaling in non-small cell lung cancer
  
  • Ponchel Théophile
  • Loeffler Emma
  • Ancel Julien
  • Brisebarre Audrey
  • Lalun Nathalie
  • Dalstein Véronique
  • Durlach Anne
  • Deslée Gaëtan
  • Dedieu Stéphane
  • Polette Myriam
  • Nawrocki-Raby Béatrice
  European Journal of Cell Biology, Elsevier, 2025, 104 (1), pp.151475. The tumor suppressor fragile histidine triad (FHIT) is frequently lost in non-small cell lung cancer (NSCLC). We previously showed that a down-regulation of FHIT causes an up-regulation of the activity of HER2 associated to an epithelial-mesenchymal transition (EMT) and that lung tumor cells harboring a FHITlow/pHER2high phenotype are sensitive to anti-HER2 drugs. Here, we sought to decipher the FHIT-regulated HER2 signaling pathway in NSCLC. Transcriptomic analysis of tumor cells isolated from NSCLC revealed the endocytic receptor low density lipoprotein receptor-related protein 1 (LRP1), a central regulator of membrane trafficking and cell signaling, as a potential player of this signaling. In a cohort of 80 NSCLC assessed by immunohistochemistry, we found a significant association between a low FHIT expression and a high pHER2 and LRP1 expression by tumor cells. Experiments of FHIT silencing showed that FHIT regulated LRP1 expression both at the mRNA and protein levels in lung cell lines. Analyzing the relationship between LRP1 and HER2, we observed that an anti-HER2 targeted therapy reversed LRP1 overexpression induced by FHIT silencing whereas LRP1 silencing did not affect HER2 activity. Studying the functional role of LRP1, we showed that cell proliferation and invasion induced by FHIT silencing were LRP1-dependent. In addition, we found that the induction of vimentin upon FHIT inactivation was counteracted by LRP1 silencing. These results suggest that LRP1 acts downstream of HER2 to induce EMT and tumor progression following FHIT loss. Dual targeting of HER2 and LRP1 might represent a therapeutic strategy to more efficiently inhibit HER2 signaling in FHIT-negative NSCLC. (10.1016/j.ejcb.2024.151475)
  DOI : 10.1016/j.ejcb.2024.151475